CRISPR vs. Cancer
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For the second time in as many week the New York Times featured an article examining some of the amazing possibilities of CRISPR.
Tmunity Therapeutics and the Parker Institute for Cancer Immunotherapy teamed up to treat three patients with advanced cancers that had progressed despite surgery, radiation, and chemotherapy treatments. The test was intended to assess and determined the safety of the treatment, with the ultimate goal of editing genes so that a patient’s own immune system to attack cancer.
CRISPR was deployed in a relatively controlled manner during the experiment, without the gene editing technology being let loose inside the patient’s bodies. Doctors instead removed T-cells from the patients’ blood and then used CRISPR to improve their ability to fight cancer, arming the T-cells to attack a protein found on cancer cells. The CRISPR was then removed from the cells before infusing the editing T-cells back into the bloodstream.
Subsequent monitoring showed a 10,000 to 100,000 fold increase in the number of T-cells growing in the patients. The cells didn’t die off and no ill effects were observed.
While the researchers stressed that this study is preliminary and does not conclusively show the edited T-cells fighting cancer.
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